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Hemodynamic effects of hydrogen sulfide, indole and tmao - gut bacteria-derived molecules: the role of the gut-blood barrier

Marcin Ufnal

Dr. Marcin Ufnal from Medical University of Warsaw, Poland, will talk about  gut bacteria and the role of the gut-blood barrier during 5th Targeting Microbiota World Congress 2017.

 "Gut bacteria produces numerous biologically active molecules which cross the gut-blood barrier and target blood vessels, the heart and other organs involved in the regulation of the circulatory system. In our laboratory we have found that hypertension is associated with an increased permeability of the colon to gut bacteria metabolites and that intracolonic administration of several gut bacteria-derived molecules significantly affects arterial blood pressure. In this paper I will present studies showing cardiovascular effects of microbiota-derived compounds such as hydrogen sulfide, indole and methylamines. Besides the effect of cardiovascular diseases on the gut-blood barrier will be discussed."

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