Bone Mass & Strength: The Role of Microbiota Derived Extracellular Vesicles

News Release, International Society of Microbiota, France – March 17, 2022

The gut microbiota (GM) has been shown to be a regulator of bone homeostasis and the mechanisms by which GM modulates bone mass is still vague.

Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength

Representative Alizarin-Red staining images of bone marrow stem cells receiving different treatments 

This study by Liu et al., reported that colonization with GM from children (CGM) but not from the elderly (EGM) prevented decreases in bone mass and bone strength in conventionally raised, ovariectomy (OVX)-induced osteoporotic mice.

16S rRNA gene sequencing revealed that CGM reverses the OVX-induced reduction of Akkermansia muciniphila (Akk). Direct replenishment of Akk was sufficient to correct the OVX-induced imbalanced bone metabolism and protect against osteoporosis.

Mechanistic studies showed that the secretion of extracellular vesicles (EVs) is required for the CGM- and Akk-induced bone protective effects and these nanovesicles can enter and accumulate into bone tissues to attenuate the OVX-induced osteoporotic phenotypes by augmenting osteogenic activity and inhibiting osteoclast formation. 

In summary, the gut bacterium Akk mediates the CGM-induced anti-osteoporotic effects and presents a novel mechanism underlying the exchange of signals between GM and host bone.

You can explore further the role of microbiota derived extracellular vesicles in health and in disease in Targeting Microbiota 2022. Professional speakers like Dr. Fermin I. Milagro will be sharing their valuable research in this field. 

Read the full article.

Media contact:
International Society of Microbiota
[email protected]

Targeting Microbiota 2022 Congress
October 19-21, 2022 - Paris, France


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